Genetic changes and growth promotion of glioblastoma by magnetic nanoparticles and a magnetic field
نویسندگان
چکیده
Aim: To confirm the biological effects of manganese ferrite magnetic nanoparticles (MFMNPs) and an external field on glioblastoma cells. Methods: U-87MG cells were prepared, into which uptake MFMNPs was high. The then exposed to using a neodymium magnet in vitro vivo. Results: LRP6 TCF7 mRNA levels involved Wnt/β-catenin signaling pathway elevated by influence field. also accelerated tumor growth approximately 7 days decreased survival rates animal experiments. Conclusion: When are applied for long time cells, expression related is increased promoted.
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ژورنال
عنوان ژورنال: Nanomedicine
سال: 2021
ISSN: ['1743-5889', '1748-6963']
DOI: https://doi.org/10.2217/nnm-2020-0399